Debate: Hodgkin lymphoma patient who relapses after autologous SCT - Allogeneic SCT



Lymphoma Relapse: Do I Need a Transplant?

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I was diagnosed five and a half years ago with a large B-cell lymphoma and had six rounds of CHOP (cyclophosphamide, doxorubicin/hydroxydoxorubicin, vincristine/Oncovin and prednisone) chemotherapy. Two and a half years later they found I had marginal zone lymphoma plasma cells, which is very rare. They watched me for two years, and after a little over a year I got Rituxan (rituximab) plus Zevalin (ibritumomab tiuxetan). That put me in a partial remission. Now I still have slow growth, but they want to treat me with six to eight rounds of R-CVP (rituximab, cyclophosphamide, vincristine and prednisone), but they think it will come back in two years. They want me to talk to possible bone marrow donors, which scares me. My only brother is not a match. Do you think I will have to have a bone marrow transplant or can I keep getting chemo and monitor the lymphoma? What is the success rate today of bone marrow transplant? I am 61 years old and in good shape. My bone marrow a month ago was okay – no evidence of lymphoma in the bone marrow.

It is unusual to relapse with a marginal zone lymphoma after successful therapy for large cell lymphoma. Marginal zone lymphoma is a slow-growing lymphoma which is not curable with standard chemotherapy. The duration of remissions tend to get shorter over time.

I agree that considering a stem cell transplant is a good idea to possibly keep the disease under control in the long term. The success rates that have been reported differ depending upon the medical center and the exact type of therapy used. I think a consultation with a stem cell transplant center near you is an excellent idea.






Video: My non-Hodgkin's lymphoma journey: Receiving the bone marrow transplant

Lymphoma Relapse: Do I Need a Transplant
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Date: 18.12.2018, 22:59 / Views: 51384